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Naltrexone by contrast is a pure opioid antagonist, therefore further augmenting bupropion s activation of the pomc.

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the mechanism by which bupropion acts as a smoking cessation aid is unclear, as is the exact mechanism of antidepressant activity.

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in primate models to assess the positive reinforcing effects of psychoactive drugs, bupropion was self-administered intravenously.

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although bupropion is not indicated for treatment of depression, it contains the same active ingredient as the antidepressant medications wellbutrin, wellbutrin sr, and wellbutrin xl.

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patients should be made aware that wellbutrin xl contains the same active ingredient found in zyban, used as an aid to smoking cessation treatment, and that wellbutrin xl should not be used in combination with zyban, or any other medications that contain bupropion, such as wellbutrin sr bupropion hydrochloride , the sustained-release formulation or wellbutrin bupropion hydrochloride , the immediate-release formulation.

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