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33 drugs or agents that increase the activity of cyp1a2, notably tobacco smoke, may significantly increase hepatic first-pass clearance of olanzapine; conversely, drugs which inhibit 1a2 activity examples ciprofloxacin, fluvoxamine may reduce olanzapine clearance.

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if the decision has been made to discontinue treatment, medication should be tapered, as rapidly as is feasible, but with recognition that abrupt discontinuation can be associated with certain symptoms see dosage and administration discontinuation of treatment with fluvoxamine maleate tablets 2.

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