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drug interactions this medicine may interact with the following medications other cholinesterase inhibitors, neuromuscular blockers, parasympathomimetics, amantadine, amiodarone, amoxapine, antiretroviral protease inhibitors, antimuscarinics, barbiturates, bosentan, carbamazepine, clozapine, cyclobenzaprine, digoxin, disopyramide, fluoxetine, flu- voxamine, fosphenytoin, general anesthetics, imatinib, st i-571, ketoconazole, local anesthetics, maprotiline, nefazodone, nilotinib, nonsteroidal anti-inflammatory drugs nsaids , olanzapine, orphenadrine, oxcarbazepine, paroxetine, phenothiazines, phe- nytoin, ranolazine, rifampin, rifapentine, sedating h1 blockers, sertraline, st.
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fluoxetine; olanzapine moderate because qt prolongation and torsade de pointes tdp have been reported in patients treated with fluoxetine, the manufacturer recommends caution when using fluoxetine with other drugs that prolong the qt interval.
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drug interactions this medicine may interact with the following medications amantadine, other cho- linesterase inhibitors, neuromuscular blockers, orphenadrine, cyclobenzaprine, parasympathomimetics, disopyramide, sedating h-1 blockers, amoxapine, antimus- carinics, clozapine, digoxin, general anesthetics, local anesthetics, maprotiline, nico- tine, nonsteroidal anti-inflammatory drugs nsaids , olanzapine, phenothiazines, nicotine smoking -may increase drug clearance, and tricyclic antidepressants.
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